Technical reference

Knowledge Centre

Peptide chemistry, purity, analytical interpretation, stability and formulation.

Technical notes from our process and QC teams — how peptides are made, how the numbers on a COA are produced, and what actually matters when you specify a grade.

7 entries

Basics

Basics

What a peptide is

A peptide is a short chain of amino acids linked by amide bonds. The convention is loose but useful: up to about 20 residues is a…

2 min read

Synthesis

Synthesis

Synthesis routes compared

Solid-phase peptide synthesis (SPPS) builds the chain on an insoluble resin, washing away reagents between couplings. It is the standard route for cosmetic and research…

2 min read

Analytics

Analytics

Reading an HPLC chromatogram

Reversed-phase HPLC separates peptides by hydrophobicity. The main peak is your product; everything else is either an impurity or an artefact of the method.

2 min read

Analytics

98 % versus 99 %

The last two percent is the expensive part, because the impurities that remain are structurally similar to the product. Going from 95 % to 98 %…

2 min read

Stability

Stability

Stability & storage

Most peptide degradation is hydrolysis, oxidation or aggregation, and all three are accelerated by water and heat. Store lyophilised powder dry and cold, typically 2–8 °C…

2 min read

Formulation

Formulation

Formulation compatibility

Keep the peptide below its isoelectric point in aqueous systems where possible; solubility is usually better away from the pI. Avoid strong oxidisers and reducing agents…

2 min read

FAQ

FAQ

Frequently asked questions

No. Price depends on sequence, purity target, scale and documentation, so a list price would be misleading. Send the specification and you get a written quotation.

2 min read